Hansen, G.; Schwarzloh, B.; Rennenberg, A.; Heussler, Volker; Hilgenfeld, R. (2011). The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis. Acta crystallographica. Section F - Structural biology and crystallization communications online, 67(Pt 11), pp. 1406-10. Oxford: Wiley-Blackwell 10.1107/S1744309111034592
Full text not available from this repository. (Request a copy)The malaria parasite Plasmodium depends on the tight control of cysteine-protease activity throughout its life cycle. Recently, the characterization of a new class of potent inhibitors of cysteine proteases (ICPs) secreted by Plasmodium has been reported. Here, the recombinant production, purification and crystallization of the inhibitory C-terminal domain of ICP from P. berghei in complex with the P. falciparum haemoglobinase falcipain-2 is described. The 1:1 complex was crystallized in space group P4(3), with unit-cell parameters a = b = 71.15, c = 120.09 A. A complete diffraction data set was collected to a resolution of 2.6 A.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology 08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria |
UniBE Contributor: |
Heussler, Volker |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1744-3091 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:27 |
Last Modified: |
05 Dec 2022 14:08 |
Publisher DOI: |
10.1107/S1744309111034592 |
PubMed ID: |
22102243 |
Web of Science ID: |
000296793300021 |
URI: |
https://boris.unibe.ch/id/eprint/10100 (FactScience: 215939) |
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