Biologically based strategies to augment rotator cuff tears

Schaer, M; Schober, M; Berger, S; Boileau, P; Zumstein, M A (2012). Biologically based strategies to augment rotator cuff tears. International journal of shoulder surgery, 6(2), pp. 51-60. Mumbai: Medknow Publications 10.4103/0973-6042.96995

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Lesions of the rotator cuff (RC) are among the most frequent tendon injuries. In spite of the developments in both open and arthroscopic surgery, RC repair still very often fails. In order to reduce the failure rate after surgery, several experimental in vitro and in vivo therapy methods have been developed for biological improvement of the reinsertion. This article provides an overview of the current evidence for augmentation of RC reconstruction with growth factors. Furthermore, potential future therapeutic approaches are discussed. We performed a comprehensive search of the PubMed database using various combinations of the keywords "tendon," "rotator cuff," "augmentation," "growth factor," "platelet-rich fibrin," and "platelet-rich plasma" for publications up to 2011. Given the linguistic capabilities of the research team, we considered publications in English, German, French, and Spanish. We excluded literature reviews, case reports, and letters to the editor.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery
UniBE Contributor:	Schober, Martin, Zumstein, Matthias
ISSN:	0973-6042
Publisher:	Medknow Publications
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:35
Last Modified:	05 Dec 2022 14:11
Publisher DOI:	10.4103/0973-6042.96995
PubMed ID:	22787334
Web of Science ID:	000305392200004
URI:	https://boris.unibe.ch/id/eprint/13876 (FactScience: 220579)