Tyrand, R; Seeck, M; Spinelli, L; Pralong, E; Vulliémoz, S; Foletti, G; Rossetti, A O; Allali, G; Lantz, G; Pollo, C; Boëx, C (2012). Effects of amygdala-hippocampal stimulation on interictal epileptic discharges. Epilepsy research, 99(1-2), pp. 87-93. Amsterdam: Elsevier 10.1016/j.eplepsyres.2011.10.026
Full text not available from this repository. (Request a copy)Deep brain stimulation (DBS) of different nuclei is being evaluated as a treatment for epilepsy. While encouraging results have been reported, the effects of changes in stimulation parameters have been poorly studied. Here the effects of changes of pulse waveform in high frequency DBS (130 Hz) of the amygdala-hippocampal complex (AH) are presented. These effects were studied on interictal epileptic discharge rates (IEDRs). AH-DBS was implemented with biphasic versus pseudo monophasic charge balanced pulses, in two groups of patients: six with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) and six with non lesional (NLES) temporal epilepsy. In patients with HS, IEDRs were significantly reduced with AH-DBS applied with biphasic pulses in comparison with monophasic pulse. IEDRs were significantly reduced in only two patients with NLES independently to stimulus waveform. Comparison to long-term seizure outcome suggests that IEDRs could be used as a neurophysiological marker of chronic AH-DBS and they suggest that the waveform of the electrical stimuli can play a major role in DBS. We concluded that biphasic stimuli are more efficient than pseudo monophasic pulses in AH-DBS in patients with HS. In patients with NLES epilepsy, other parameters relevant for efficacy of DBS remain to be determined.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Pollo, Claudio |
ISSN: |
0920-1211 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1016/j.eplepsyres.2011.10.026 |
PubMed ID: |
22079883 |
Web of Science ID: |
000302431700011 |
URI: |
https://boris.unibe.ch/id/eprint/14841 (FactScience: 221975) |
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