Denton, Paul W; Olesen, Rikke; Choudhary, Shailesh K; Archin, Nancy M; Wahl, Angela; Swanson, Michael D; Chateau, Morgan; Nochi, Tomonori; Krisko, John F; Spagnuolo, Rae Ann; Margolis, David M; Garcia, J Victor (2012). Generation of HIV latency in humanized BLT mice. Journal of virology, 86(1), pp. 630-4. Baltimore: American Society for Microbiology 10.1128/JVI.06120-11
Full text not available from this repository. (Request a copy)Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4+ T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting human CD4+ T cells present in BLT mice are within the range of those observed circulating in patients undergoing suppressive ART. These results demonstrate the potential of humanized BLT mice as an attractive model for testing the in vivo efficacy of novel HIV eradication strategies.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Wahl, Andreas |
ISSN: |
0022-538X |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1128/JVI.06120-11 |
PubMed ID: |
22013053 |
Web of Science ID: |
000298347700065 |
URI: |
https://boris.unibe.ch/id/eprint/15005 (FactScience: 222155) |
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