[Approach to prostate cancer in men older than 75 years: active or passive?]

Spahn, M; Haeni, K (2012). [Approach to prostate cancer in men older than 75 years: active or passive?]. Urologe, 51(10), pp. 1368-74. Berlin: Springer-Verlag 10.1007/s00120-012-3011-6

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Based on the exponential aging of the population and the increasing life expectancy in industrialized western countries, prostate cancer (PCa) in elderly men is becoming a disease of increasing significance. Consensus exists that men over the age of 75 years should not be screened for PCa; however, higher age as a single parameter should not exclude men from being diagnosed with prostate cancer and treated accordingly. It is well-known that overdiagnosis and overtreatment are frequent in this age group. Competing mortality risks of men older than 75 years may supersede the risk of dying from PCa several fold. Both the treating physician and the patient himself should therefore balance the possible risks and benefits of diagnosing and treating prostate cancer concerning the impact on quality of life. This is of special importance when taking into account that the complication rates of curative treatment modalities are higher in older patients than in younger men and that hormonal treatment might have negative effects especially in older men.Age, existing comorbidities, cognitive and physical status in combination with specific tumor parameters are useful tools for an individualized treatment.Therapy should be considered for healthy, active men aged 75 years or older who present with high-risk PCa and/or with a PSA doubling time <12 months. Elderly men who are unfit or have low to intermediate risk PCa will most likely not benefit from treatment.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Spahn, Martin

ISSN:

0340-2592

Publisher:

Springer-Verlag

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

05 Dec 2022 14:12

Publisher DOI:

10.1007/s00120-012-3011-6

PubMed ID:

23053031

Web of Science ID:

000309561000004

BORIS DOI:

10.7892/boris.15456

URI:

https://boris.unibe.ch/id/eprint/15456 (FactScience: 222803)

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