Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate

Joerger, Markus; Ferreri, Andrés J M; Krähenbühl, Stephan; Schellens, Jan H M; Cerny, Thomas; Zucca, Emanuele; Huitema, Alwin D R (2012). Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate. British journal of clinical pharmacology, 73(2), pp. 240-7. Oxford: Wiley-Blackwell 10.1111/j.1365-2125.2011.04084.x

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There is no consensus regarding optimal dosing of high dose methotrexate (HDMTX) in patients with primary CNS lymphoma. Our aim was to develop a convenient dosing algorithm to target AUC(MTX) in the range between 1000 and 1100 µmol l(-1) h.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Krähenbühl-Melcher, Stephan

ISSN:

0306-5251

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

02 Mar 2023 23:21

Publisher DOI:

10.1111/j.1365-2125.2011.04084.x

PubMed ID:

21838788

Web of Science ID:

000298876300011

URI:

https://boris.unibe.ch/id/eprint/15652 (FactScience: 223063)

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