Lucchini, Barbara; Simonetti, Giacomo D; Ceschi, Alessandro; Lava, Sebastiano A G; Faré, Pietro B; Bianchetti, Mario G (2013). Severe signs of hyponatremia secondary to desmopressin treatment for enuresis: A systematic review. Journal of pediatric urology, 9(6 Pt B), pp. 1049-1053. Amsterdam: Elsevier
Full text not available from this repository. (Request a copy)OBJECTIVE: Dilutional hyponatremia is a serious adverse effect of desmopressin, a vasopressin analog that is widely prescribed to manage monosymptomatic enuresis. The presentation of hyponatremia, largely related to cerebral dysfunction, can include severe signs like altered mental status and seizures. METHODS: We reviewed the literature dealing with altered mental status or seizures in enuretic subjects on desmopressin. The retained publications included patients who were described individually, revealing data on mode of administration, further identifiable factors predisposing to hyponatremia, presentation and clinical course. RESULTS: We found 54 cases of hyponatremia secondary to desmopressin treatment presenting with altered mental status or seizures. In most cases the complication developed 14 days or less after starting desmopressin. An intranasal formulation had been used in 47 patients. Excess fluid intake was documented as a contributing factor in at least 22 cases. In 6 cases severe signs of hyponatremia developed in the context of intercurrent illnesses. CONCLUSION: Altered mental status or seizures are very rare but recognized complications of desmopressin in enuresis. This complication mostly develops in subjects managed with the intranasal formulation 14 days or less after starting the medication, following excess fluid intake and during intercurrent illnesses.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Simonetti, Giacomo |
ISSN: |
1477-5131 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:41 |
Last Modified: |
05 Dec 2022 14:12 |
PubMed ID: |
23619353 |
URI: |
https://boris.unibe.ch/id/eprint/16571 (FactScience: 224239) |
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