Gualco, Gianluca; Lava, Sebastiano A G; Garzoni, Luca; Simonetti, Giacomo D; Bettinelli, Alberto; Milani, Gregorio P; Provero, Maria Cristina; Bianchetti, Mario G (2013). Transient Benign Hyperphophatasemia - A Systematic Review of The Literature. Journal of pediatric gastroenterology and nutrition, 57(2), pp. 167-171. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MPG.0b013e318162c428
Full text not available from this repository. (Request a copy)BACKGROUND:: Sometimes, a temporary increase in alkaline phosphatase level is found in healthy infants and toddlers without evidence of liver or bone disease. The condition is customarily termed transient benign hyperphosphatasemia of infancy and early childhood. Most textbooks do not refer to the condition. METHODS:: We completed a systematic review of the literature using the principles underlying the UK Economic and Social Research Council guidance on the conduct of narrative synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. RESULTS:: The 142 reports retained for analysis included 813 cases (male:female ratio = 1.1:1.0): 80 in subjects >18 years and 733 in subjects ≤18 years of age. The alkaline phosphatase ratio, calculated by dividing the measured level by the upper normal limit, was ≥5.0 in ≈70% and the duration of the elevation ≤4 months in 80% of the cases. Transient benign hyperphosphatasemia often followed a benign infection but available data fail to demonstrate a causal link. The prevalence of transient benign hyperphosphatasemia ranged 1.1-3.5% in infants 2 to 24 months of age. CONCLUSIONS:: Transient benign hyperphosphatasemia is likely the most common cause of hyperphosphatasemia among healthy infants and toddlers. Sometimes, it also occurs in older children and adults, indicating that the traditional term transient benign hyperphosphatasemia of infancy and early childhood might not be correct. The elevation in alkaline phosphatase persists for >4 months in ≈20% of the cases. Recognition of this benign condition is crucial to avoid unnecessary investigations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Simonetti, Giacomo |
ISSN: |
0277-2116 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:41 |
Last Modified: |
05 Dec 2022 14:12 |
Publisher DOI: |
10.1097/MPG.0b013e318162c428 |
PubMed ID: |
23539049 |
Web of Science ID: |
000258009700011 |
URI: |
https://boris.unibe.ch/id/eprint/16574 (FactScience: 224242) |
Actions (login required)
 |
Edit item |