Nephrolithiasis-associated bone disease: pathogenesis and treatment options

Sakhaee, Khashayar; Maalouf, Naim M; Kumar, Rajiv; Pasch, Andreas; Moe, Orson W (2011). Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney international, 79(4), pp. 393-403. New York, N.Y.: Nature Publishing Group 10.1038/ki.2010.473

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Nephrolithiasis remains a formidable health problem in the United States and worldwide. A very important but underaddressed area in nephrolithiasis is the accompanying bone disease. Epidemiologic studies have shown that osteoporotic fractures occur more frequently in patients with nephrolithiasis than in the general population. Decreased bone mineral density and defects in bone remodeling are commonly encountered in patients with calcium nephrolithiasis. The pathophysiologic connection of bone defects to kidney stones is unknown. Hypercalciuria and hypocitraturia are two important risk factors for stone disease, and treatments with thiazide diuretics and alkali, respectively, have been shown to be useful in preventing stone recurrence in small prospective trials. However, no studies have examined the efficacy of these agents or other therapies in preventing continued bone loss in calcium stone formers. This manuscript reviews the epidemiology, pathophysiology, and potential treatments of bone disease in patients with nephrolithiasis.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Pasch, Andreas
ISSN:	0085-2538
Publisher:	Nature Publishing Group
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:11
Last Modified:	05 Dec 2022 14:01
Publisher DOI:	10.1038/ki.2010.473
PubMed ID:	21124301
Web of Science ID:	000286726500005
URI:	https://boris.unibe.ch/id/eprint/1788 (FactScience: 203814)