Sugar modification as a means to increase the biological performance of oligonucleotides

Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167

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Modification of the ribose unit in DNA and RNA profoundly influences the self-rcognition and the biological properties of the nucleic acids. Conformational restriction of the ribose units, as in LNA and tricyclo-DNA, has been identified as a powerful tool to increase DNA and RNA affinity as well as biological stability and antisense properties. Apart from that sugar modified DNA analogues, as homo-DNA, have shown to be orthogonal base-pairing systems which by virtue of non-crosscommunicating with the natural nucleic acids open novel applications in biotechnology.

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