Dobbelaere, Dirk; Rottenberg, Sven (2003). Theileria-induced leukocyte transformation. Current opinion in microbiology, 6(4), pp. 377-382. London: Current Biology Ltd. 10.1016/S1369-5274(03)00085-7
Full text not available from this repository. (Request a copy)The intracellular protozoan parasites Theileria parva and T. annulata transform the cells they infect, inducing uncontrolled proliferation. This is not a trivial event as, in addition to permanently switching on the complex pathways that govern all steps of the cell cycle, the built-in apoptotic safety mechanisms that prevent 'illegitimate' cell replication also need to be inactivated. Recent experiments show that the NF-kappa B and phosphoinositide 3-kinase (PtdIns-3K) pathways are important participants in the transformation process. I kappa B kinase (IKK), a pivotal kinase complex in the NF-kappa B pathway, is recruited to the parasite surface where it becomes activated. The PtdIns-3K/Akt/PKB pathway is also constitutively activated in a parasite-dependent manner, but contrary to IKK, activation is probably not triggered by direct association with the parasite.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology |
UniBE Contributor: |
Dobbelaere, Dirk,, Rottenberg, Sven |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1369-5274 |
Publisher: |
Current Biology Ltd. |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:44 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1016/S1369-5274(03)00085-7 |
PubMed ID: |
12941408 |
Web of Science ID: |
000185173000011 |
URI: |
https://boris.unibe.ch/id/eprint/18407 (FactScience: 461) |
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