Pain, A; Renauld, H; Berriman, M; Murphy, L; Yeats, CA; Weir, W; Kerhornou, A; Aslett, M; Bishop, R; Bouchier, C; Cochet, M; Coulson, RM; Cronin, A; de Villiers, EP; Fraser, A; Fosker, N; Gardner, M; Goble, A; Griffiths-Jones, S; Harris, D.E.; ... (2005). Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science, 5731(309), pp. 131-3. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1110418
Full text not available from this repository. (Request a copy)Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology |
UniBE Contributor: |
Dobbelaere, Dirk, |
ISSN: |
0036-8075 |
Publisher: |
American Association for the Advancement of Science |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:44 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1126/science.1110418 |
PubMed ID: |
15994557 |
Web of Science ID: |
000230212800075 |
URI: |
https://boris.unibe.ch/id/eprint/18410 (FactScience: 464) |
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