Babiychuk, E B; Draeger, A (2006). Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement? Biochemical Society transactions, 34(Pt 3), pp. 374-6. London: Portland Press
Full text not available from this repository. (Request a copy)The spatial segregation of the plasma membrane plays a prominent role in distinguishing and sorting a large number of signals a cell receives simultaneously. The plasma membrane comprises regions known as lipid rafts, which serve as signal-transduction hubs and platforms for sorting membrane-associated proteins. Ca(2+)-binding proteins of the annexin family have been ascribed a role in the regulation of raft dynamics. Glycosylphosphatidylinositol-anchored 5'-nucleotidase is an extracellular, raft-associated enzyme responsible for conversion of extracellular ATP into adenosine. Our results point to a regulation of ecto-5'-nucleotidase activity by Ca(2+)-dependent, annexin-mediated stabilization of membrane rafts.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy |
UniBE Contributor: |
Babiichuk, Eduard, Draeger, Annette |
ISSN: |
0300-5127 |
ISBN: |
16709165 |
Publisher: |
Portland Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:46 |
Last Modified: |
02 Mar 2023 23:22 |
PubMed ID: |
16709165 |
Web of Science ID: |
000238630000011 |
URI: |
https://boris.unibe.ch/id/eprint/18923 (FactScience: 1194) |
Actions (login required)
 |
Edit item |