Lung fluid movements in hypoxia

Sartori, Claudio; Rimoldi, Stefano F; Scherrer, Urs (2010). Lung fluid movements in hypoxia. Progress in cardiovascular diseases, 52(6), pp. 493-9. Orlando, Fla.: Elsevier 10.1016/j.pcad.2010.02.005

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Pulmonary edema is a problem of major clinical importance resulting from a persistent imbalance between forces that drive water into the airspace of the lung and the biological mechanisms for its removal. Here, we will first review the fundamental mechanisms implicated in the regulation of lung fluid homeostasis, namely, the Starling forces and the respiratory transepithelial sodium transport. Second, we will discuss the contribution of hypoxia to the perturbation of this fine balance and the role of such perturbations in the development of high-altitude pulmonary edema, a disease characterized by a very high morbidity and mortality. Finally, we will review possible interventions aimed to maintain/restore lung fluid homeostasis and their importance for the prevention/treatment of pulmonary edema.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Rimoldi, Stefano
ISSN:	0033-0620
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:11
Last Modified:	05 Dec 2022 14:01
Publisher DOI:	10.1016/j.pcad.2010.02.005
PubMed ID:	20417342
Web of Science ID:	000277309600006
URI:	https://boris.unibe.ch/id/eprint/1896 (FactScience: 203943)