Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study

Rau, Philipp R; Sellner, Johann; Heiland, Sabine; Plaschke, Konstanze; Schellinger, Peter D; Meyding-Lamadé, Uta K; Lamadé, Wolfram R (2006). Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study. Life sciences, 78(11), pp. 1175-80. Amsterdam: Elsevier 10.1016/j.lfs.2005.06.032

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Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects of aging on diffusion are yet to be determined. To establish reference values for future experimental mouse studies we tested the hypothesis that absolute apparent diffusion coefficients (ADC) of the normal brain change with age. A total of 41 healthy mice were examined by T2-weighted imaging and DWI. For each animal ADC frequency histograms (i) of the whole brain were calculated on a voxel-by-voxel basis and region-of-interest (ROI) measurements (ii) performed and related to the animals' age. The mean entire brain ADC of mice <3 months was 0.715(+/-0.016) x 10(-3) mm2/s, no significant difference to mice aged 4 to 5 months (0.736(+/-0.040) x 10(-3) mm2/s) or animals older than 9 months 0.736(+/-0.020) x 10(-3) mm2/s. Mean whole brain ADCs showed a trend towards lower values with aging but both methods (i + ii) did not reveal a significant correlation with age. ROI measurements in predefined areas: 0.723(+/-0.057) x 10(-3) mm2/s in the parietal lobe, 0.659(+/-0.037) x 10(-3) mm2/s in the striatum and 0.679(+/-0.056) x 10(-3) mm2/s in the temporal lobe. With advancing age, we observed minimal diffusion changes in the whole mouse brain as well as in three ROIs by determination of ADCs. According to our data ADCs remain nearly constant during the aging process of the brain with a small but statistically non-significant trend towards a decreased diffusion in older animals.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Sellner, Johann

ISSN:

0024-3205

ISBN:

16213530

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

05 Dec 2022 14:14

Publisher DOI:

10.1016/j.lfs.2005.06.032

PubMed ID:

16213530

Web of Science ID:

000235402000005

URI:

https://boris.unibe.ch/id/eprint/19106 (FactScience: 1477)

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