Kessler, U; Mungnirandr, A; Nelle, M; Nimmo, A F; Zachariou, Z; Berger, S (2006). A simple presurgical necrotizing enterocolitis-mortality scoring system. Journal of perinatology, 26(12), pp. 764-8. New York, N.Y.: Nature Publishing Group 10.1038/sj.jp.7211613
Full text not available from this repository. (Request a copy)OBJECTIVE: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). STUDY DESIGN: Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein). RESULTS: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively. CONCLUSION: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Kessler, Ulf, Nelle, Mathias, Zachariou, Zacharias |
ISSN: |
0743-8346 |
ISBN: |
17122786 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:46 |
Last Modified: |
05 Dec 2022 14:14 |
Publisher DOI: |
10.1038/sj.jp.7211613 |
PubMed ID: |
17122786 |
Web of Science ID: |
000242246000009 |
URI: |
https://boris.unibe.ch/id/eprint/19278 (FactScience: 1777) |
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