Berthier, Céline; Marti, Hans-Peter (2006). Metzincins, including matrix metalloproteinases and meprin, in kidney transplantation. Swiss medical weekly, 136(49-50), pp. 789-94. Muttenz: EMH Schweizerischer Ärzteverlag
Full text not available from this repository. (Request a copy)Chronic allograft nephropathy, including chronic rejection, remains one of the major causes of renal allograft failure. Amongst other mediators, metzincins, such as matrix metalloproteinases (MMP), direct extracellular matrix metabolism and cell proliferation. Thus, we hypothesized, that these proteolytic enzymes are differentially regulated in chronic renal transplant rejection in rats and in human renal allograft nephropathy. Our studies demonstrated on the experimental level and in humans an overall up-regulation of MMP, tissue inhibitors of metalloproteinases (TIMP) and related enzymes as a result of rejection processes. Thus, metzincins may represent novel markers and therapeutic targets with respect to renal allograft rejection.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Marti, Hans-Peter |
ISSN: |
1424-7860 |
ISBN: |
17299656 |
Publisher: |
EMH Schweizerischer Ärzteverlag |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:47 |
Last Modified: |
05 Dec 2022 14:14 |
PubMed ID: |
17299656 |
Web of Science ID: |
000243544500002 |
URI: |
https://boris.unibe.ch/id/eprint/19816 (FactScience: 2794) |
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