Disruption of glucocorticoid action by environmental chemicals: potential mechanisms and relevance

Odermatt, Alex; Gumy, Christel; Atanasov, Atanas G; Dzyakanchuk, Anna A (2006). Disruption of glucocorticoid action by environmental chemicals: potential mechanisms and relevance. Journal of steroid biochemistry and molecular biology, 102(1-5), pp. 222-31. Amsterdam: Elsevier 10.1016/j.jsbmb.2006.09.010

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Glucocorticoids play an essential role in the regulation of key physiological processes, including immunomodulation, brain function, energy metabolism, electrolyte balance and blood pressure. Exposure to naturally occurring compounds or industrial chemicals that impair glucocorticoid action may contribute to the increasing incidence of cognitive deficits, immune disorders and metabolic diseases. Potentially, "glucocorticoid disruptors" can interfere with various steps of hormone action, e.g. hormone synthesis, binding to plasma proteins, delivery to target cells, pre-receptor regulation of the ratio of active versus inactive hormones, glucocorticoid receptor (GR) function, or export and degradation of glucocorticoids. Several recent studies indicate that such chemicals exist and that some of them can cause multiple toxic effects by interfering with different steps of hormone action. For example, increasing evidence suggests that organotins disturb glucocorticoid action by altering the function of factors that regulate the expression of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) pre-receptor enzymes, by direct inhibition of 11beta-HSD2-dependent inactivation of glucocorticoids, and by blocking GR activation. These observations emphasize on the complexity of the toxic effects caused by such compounds and on the need of suitable test systems to assess their effects on each relevant step.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Odermatt, Alexander
ISSN:	0960-0760
ISBN:	17045799
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:47
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1016/j.jsbmb.2006.09.010
PubMed ID:	17045799
Web of Science ID:	000242875300028
URI:	https://boris.unibe.ch/id/eprint/19821 (FactScience: 2803)