Germanier, Yves; Tosatti, Samuele; Broggini, Nina; Textor, Marcus; Buser, Daniel (2006). Enhanced bone apposition around biofunctionalized sandblasted and acid-etched titanium implant surfaces. A histomorphometric study in miniature pigs. Clinical oral implants research, 17(3), pp. 251-257. Oxford: Wiley-Blackwell 10.1111/j.1600-0501.2005.01222.x
Full text not available from this repository. (Request a copy)Microrough titanium (Ti) surfaces of dental implants have demonstrated more rapid and greater bone apposition when compared with machined Ti surfaces. However, further enhancement of osteoblastic activity and bone apposition by bio-functionalizing the implant surface with a monomolecular adsorbed layer of a co-polymer - i.e., poly(L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) and its derivatives (PLL-g-PEG/PEG-peptide) - has never been investigated. The aim of the present study was to examine early bone apposition to a modified sandblasted and acid-etched (SLA) surface coated with an Arg-Gly-Asp (RGD)-peptide-modified polymer (PLL-g-PEG/PEG-RGD) in the maxillae of miniature pigs, and to compare it with the standard SLA surface. Test and control implants had the same microrough topography (SLA), but differed in their surface chemistry (polymer coatings). The following surfaces were examined histomorphometrically: (i) control - SLA without coating; (ii) (PLL-g-PEG); (iii) (PLL-g-PEG/PEG-RDG) (RDG, Arg-Asp-Gly); and (iv) (PLL-g-PEG/PEG-RGD). At 2 weeks, RGD-coated implants demonstrated significantly higher percentages of bone-to-implant contact as compared with controls (61.68% vs. 43.62%; P < 0.001). It can be concluded that the (PLL-g-PEG/PEG-RGD) coatings may promote enhanced bone apposition during the early stages of bone regeneration.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology |
UniBE Contributor: |
Germanier, Yves, Broggini, Nina, Buser, Daniel Albin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0905-7161 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
04 Oct 2013 14:48 |
Last Modified: |
02 Mar 2023 23:22 |
Publisher DOI: |
10.1111/j.1600-0501.2005.01222.x |
PubMed ID: |
16672019 |
Web of Science ID: |
000237259500003 |
URI: |
https://boris.unibe.ch/id/eprint/20018 (FactScience: 3099) |
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