Walther, Sebastian; Baciu, Dan (2006). [No rebound psychosis in a case of switching from clozapine to quetiapine]. Psychiatrische Praxis, 33(2), pp. 93-4. Stuttgart: Thieme 10.1055/s-2005-866987
Full text not available from this repository. (Request a copy)OBJECTIVE: After rapid discontinuation of clozapine treatment rebound psychosis have been reported. Preexposure of D (2) receptors to clozapine may alter their affinity to endogenous dopamine. Clozapine withdrawal may also lead dysfunctional NMDA-receptors to cause dopamine release in the striatum. METHOD: We report a case of a schizophrenic patient treated with clozapine 200 mg and aripiprazole 15 mg per day. After rapid clozapine discontinuation we added quetiapine up to 700 mg daily. RESULTS: No rebound psychosis occurred. Even ten weeks after switching to quetiapine the patient's condition remained stable in the Brief Psychiatric Rating Scale. CONCLUSIONS: The combination of aripiprazole and quetiapine seemed to control supersensitivity effects at the D (2) receptor after clozapin withdrawal in this case.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management |
UniBE Contributor: |
Walther, Sebastian, Baciu, Dan |
ISSN: |
0303-4259 |
ISBN: |
16502388 |
Publisher: |
Thieme |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:48 |
Last Modified: |
05 Dec 2022 14:15 |
Publisher DOI: |
10.1055/s-2005-866987 |
PubMed ID: |
16502388 |
Web of Science ID: |
000235955000008 |
URI: |
https://boris.unibe.ch/id/eprint/20046 (FactScience: 3128) |
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