Henschen, M; Stocks, J; Brookes, I; Frey, U (2006). New aspects of airway mechanics in pre-term infants. European respiratory journal, 27(5), pp. 913-20. Sheffield, UK: European Respiratory Society 10.1183/09031936.06.00036305
Full text not available from this repository. (Request a copy)High-frequency respiratory impedance data measured noninvasively by the high-speed interrupter technique (HIT), particularly the first antiresonance frequency (f(ar,1)), is related to airway wall mechanics. The aim of this study was to evaluate the feasibility and repeatability of HIT in unsedated pre-term infants, and to compare values of f(ar,1) from 18 pre-term (post-conceptional age 32-37 weeks, weight 1,730-2,910 g) and 18 full-term infants (42-47 weeks, 3,920-5,340 g). Among the pre-term infants, there was good short-term repeatability of f(ar,1) within a single sleep epoch (mean (sd) coefficient of variance: 8 (1.7)%), but 95% limits of agreement for repeated measures of f(ar,1) after 3-8 h were relatively wide (-41 Hz; 37 Hz). f(ar,1) was significantly lower in pre-term infants (199 versus 257 Hz), indicating that wave propagation characteristics in pre-term airways are different from those of full-term infants. The present authors suggest that this is consistent with developmental differences in airway wall structure and compliance, including the influence of the surrounding tissue. Since flow limitation is determined by wave propagation velocity and airway cross-sectional area, it was hypothesised that the physical ability of the airways to carry large flows is fundamentally different in pre-term than in full-term infants.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Frey, Urs Peter |
ISSN: |
0903-1936 |
ISBN: |
16455837 |
Publisher: |
European Respiratory Society |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:50 |
Last Modified: |
05 Dec 2022 14:15 |
Publisher DOI: |
10.1183/09031936.06.00036305 |
PubMed ID: |
16455837 |
Web of Science ID: |
000237237100011 |
URI: |
https://boris.unibe.ch/id/eprint/20908 (FactScience: 4704) |
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