A pharmaco-EEG study on antipsychotic drugs in healthy volunteers

Yoshimura, Masafumi; Koenig, Thomas; Irisawa, Satoshi; Isotani, Toshiaki; Yamada, Keizo; Kikuchi, Mitsuru; Okugawa, Gaku; Yagyu, Takami; Kinoshita, Toshihiko; Strik, Werner; Dierks, Thomas (2007). A pharmaco-EEG study on antipsychotic drugs in healthy volunteers. Psychopharmacology, 191(4), pp. 995-1004. Berlin: Springer 10.1007/s00213-007-0737-8

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RATIONALE: Both psychotropic drugs and mental disorders have typical signatures in quantitative electroencephalography (EEG). Previous studies found that some psychotropic drugs had EEG effects opposite to the EEG effects of the mental disorders treated with these drugs (key-lock principle). OBJECTIVES: We performed a placebo-controlled pharmaco-EEG study on two conventional antipsychotics (chlorpromazine and haloperidol) and four atypical antipsychotics (olanzapine, perospirone, quetiapine, and risperidone) in healthy volunteers. We investigated differences between conventional and atypical drug effects and whether the drug effects were compatible with the key-lock principle. METHODS: Fourteen subjects underwent seven EEG recording sessions, one for each drug (dosage equivalent of 1 mg haloperidol). In a time-domain analysis, we quantified the EEG by identifying clusters of transiently stable EEG topographies (microstates). Frequency-domain analysis used absolute power across electrodes and the location of the center of gravity (centroid) of the spatial distribution of power in different frequency bands. RESULTS: Perospirone increased duration of a microstate class typically shortened in schizophrenics. Haloperidol increased mean microstate duration of all classes, increased alpha 1 and beta 1 power, and tended to shift the beta 1 centroid posterior. Quetiapine decreased alpha 1 power and shifted the centroid anterior in both alpha bands. Olanzapine shifted the centroid anterior in alpha 2 and beta 1. CONCLUSIONS: The increased microstate duration under perospirone and haloperidol was opposite to effects previously reported in schizophrenic patients, suggesting a key-lock mechanism. The opposite centroid changes induced by olanzapine and quetiapine compared to haloperidol might characterize the difference between conventional and atypical antipsychotics.

Item Type: Journal Article (Original Article)
Division/Institute: 07 Faculty of Human Sciences > Institute of Psychology > Experimental Psychology and Neuropsychology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
UniBE Contributor: König, Thomas; Strik, Werner and Dierks, Thomas
ISSN: 0033-3158
Publisher: Springer
Language: English
Submitter: Factscience Import
Date Deposited: 04 Oct 2013 14:51
Last Modified: 06 Dec 2013 13:44
Publisher DOI: 10.1007/s00213-007-0737-8
PubMed ID: 17333135
Web of Science ID: 000244824400014
URI: http://boris.unibe.ch/id/eprint/21532 (FactScience: 7342)

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