Kaiser, Marcel; Wittlin, Sergio; Nehrbass-Stuedli, Angela; Dong, Yuxiang; Wang, Xiaofang; Hemphill, Andrew; Matile, Hugues; Brun, Reto; Vennerstrom, Jonathan L (2007). Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrobial agents and chemotherapy, 51(8), pp. 2991-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00225-07
Full text not available from this repository. (Request a copy)Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology |
UniBE Contributor: |
Hemphill, Andrew |
ISSN: |
0066-4804 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1128/AAC.00225-07 |
PubMed ID: |
17562801 |
Web of Science ID: |
000248523700047 |
URI: |
https://boris.unibe.ch/id/eprint/22732 (FactScience: 36364) |
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