Simonetti, G; Mohaupt, M (2007). [Calcium and blood pressure]. Therapeutische Umschau, 64(5), pp. 249-52. Bern: Huber 10.1024/0040-5930.64.5.249
Full text not available from this repository. (Request a copy)The regulation of blood pressure is complex with several organs being involved. Intracellular calcium plays a crucial role in the regulation of cardiovascular functions: An increased influx of calcium into the vascular smooth muscle cells leads to an augmental muscular tone and therefore to an increased vascular resistance and rise in blood pressure. Parathormone plays a permissive role since it regulates the calcium-influx into the cells and thus increases the vasoconstrictive effect. There is a positive correlation between parathormone and blood pressure, present in primary as well as secondary hyperparathyroidism. Moreover, patients with essential hypertension have high parathormone levels already before hypertension is diagnosed. A calcium-rich diet (> 1000 mg calcium daily) slightly decreases blood pressure. This positive effect is due to parathormone suppression with a subsequently decreased calcium content in the vascular smooth muscle cells. A calcium-rich diet inhibits lipogenesis in the fat tissue; thus additionally improving the cardiovascular risk profile.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Mohaupt, Markus |
ISSN: |
0040-5930 |
ISBN: |
17685082 |
Publisher: |
Huber |
Language: |
English |
Submitter: |
Markus Georg Mohaupt |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1024/0040-5930.64.5.249 |
PubMed ID: |
17685082 |
Web of Science ID: |
A1983QT02300008 |
URI: |
https://boris.unibe.ch/id/eprint/23028 (FactScience: 38661) |
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