Six-year follow-up of azathioprine and mycophenolate mofetil use during the first 6 months of renal transplantation

Rippin, S J; Serra, A L; Marti, H P; Wüthrich, R P (2007). Six-year follow-up of azathioprine and mycophenolate mofetil use during the first 6 months of renal transplantation. Clinical nephrology, 67(6), pp. 374-80. München-Deisenhofen: Dustri-Verlag

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Long-term follow-up examination to test whether therapy with mycophenolate mofetil (MMF) or azathioprine (AZA) during the first year translates into different graft or patient survival and graft function is important. Therefore, 6-year follow-up data of a group of 80 consecutive renal transplant recipients were analyzed. The first group of 40 patients was treated with AZA, cyclosporine and prednisone and the second group with MMF, cyclosporine and prednisone for the first 6 months. Graft failure rates were compared during follow-up. Creatinine, inverse slope of creatinine (delta/creatinine) and 24-hour proteinuria at 6 years post transplantation were compared. The Kaplan-Meier analyses for death-censored and non-censored graft failure showed no difference between the groups. Creatinine values at 6 years for the AZA Group were 139 +/- 36 micromol/l (95% CI 125.9-151.2 micromol/l) and for the MMF Group 149 +/- 52 micromol/l (95% CI 133.9-164.9 micromol/l). Delta/creatinine and 24-hour proteinuria at 6 years did not differ between the two groups. We conclude that an initial 6-month treatment with MMF as opposed to AZA reduced the early rejection rate, but did not result in superior long-term graft function or survival after 6 years of follow-up observation.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Marti, Hans-Peter
ISSN:	0301-0430
ISBN:	17598373
Publisher:	Dustri-Verlag
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:54
Last Modified:	05 Dec 2022 14:16
PubMed ID:	17598373
Web of Science ID:	000247600400007
URI:	https://boris.unibe.ch/id/eprint/23039 (FactScience: 38689)