Reiter, Elke; Jiang, Qing; Christen, Stephan (2007). Anti-inflammatory properties of alpha- and gamma-tocopherol. Molecular aspects of medicine, 28(5-6), pp. 668-91. Amsterdam: Elsevier 10.1016/j.mam.2007.01.003
Full text not available from this repository. (Request a copy)Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin E, alpha-tocopherol (alphaT) and gamma-tocopherol (gammaT), and discuss the potential molecular mechanisms involved in these effects. While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gammaT-enriched) tocopherols seems to be more potent than supplementation with alphaT alone. This may explain the mostly negative outcomes of the recent large-scale interventional chronic disease prevention trials with alphaT only and thus warrants further investigation.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Christen, Stephan |
ISSN: |
0098-2997 |
ISBN: |
17316780 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1016/j.mam.2007.01.003 |
PubMed ID: |
17316780 |
Web of Science ID: |
000251145200012 |
URI: |
https://boris.unibe.ch/id/eprint/23290 (FactScience: 41017) |
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