Guarda, Greta; Hons, Miroslav; Soriano, Silvia F; Huang, Alex Y; Polley, Rosalind; Martín-Fontecha, Alfonso; Stein, Jens V; Germain, Ronald N; Lanzavecchia, Antonio; Sallusto, Federica (2007). L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nature immunology, 8(7), pp. 743-52. New York, N.Y.: Nature Publishing Group 10.1038/ni1469
Full text not available from this repository. (Request a copy)T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Hons, Miroslav, Stein, Jens Volker |
ISSN: |
1529-2908 |
ISBN: |
17529983 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1038/ni1469 |
PubMed ID: |
17529983 |
Web of Science ID: |
000247718100015 |
URI: |
https://boris.unibe.ch/id/eprint/23661 (FactScience: 43328) |
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