Cottagnoud, P; Acosta, F; Cottagnoud, M; Täuber, MG (2002). Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumococci in experimental meningitis. Antimicrobial agents and chemotherapy, 46(5), pp. 1607-9. Washington, D.C.: American Society for Microbiology 10.1128/AAC.46.5.1607-1609-2002
Full text not available from this repository. (Request a copy)In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Deltalog(10)] CFU/ml/h, -0.68 +/- 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 +/- 0.09 deltalog(10) CFU/ml/h), in the treatment of meningitis due to a penicillin-resistant pneumococcal strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, gemifloxacin showed good bactericidal activity (-0.48 +/- 0.16 deltalog(10) CFU/ml/h). The excellent antibacterial activity of gemifloxacin was also confirmed by time-kill assays over 8 h in vitro.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0066-4804 |
ISBN: |
11959614 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1128/AAC.46.5.1607-1609-2002 |
PubMed ID: |
11959614 |
Web of Science ID: |
000175100800074 |
URI: |
https://boris.unibe.ch/id/eprint/25731 (FactScience: 60830) |
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