Cottagnoud, P; Acosta, F; Cottagnoud, M; Täuber, MG (2002). Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis. Journal of antimicrobial chemotherapy, 49(2), pp. 327-30. Oxford: Oxford University Press 10.1093/jac/49.2.327
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In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Delta log(10) cfu/mL x h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 +/- 0.14 Delta log(10) cfu/mL x h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0305-7453 |
ISBN: |
11815575 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
21 Feb 2023 15:36 |
Publisher DOI: |
10.1093/jac/49.2.327 |
PubMed ID: |
11815575 |
Web of Science ID: |
000173960000015 |
BORIS DOI: |
10.7892/boris.25734 |
URI: |
https://boris.unibe.ch/id/eprint/25734 (FactScience: 60836) |
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