Röth, Alexander; de Beer, Dirk; Nückel, Holger; Sellmann, Ludger; Dührsen, Ulrich; Dürig, Jan; Baerlocher, Gabriela M (2008). Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia. British journal of haematology, 143(3), pp. 383-6. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2008.07363.x
Full text not available from this repository. (Request a copy)In contrast to other B-cell neoplasias, chronic lymphocytic leukaemia (CLL) is characterized by increased non-leukaemic T-cells. In order to assess their replicative history, telomere length was analyzed in subsets of leucocytes from CLL patients. Naive and memory T-cells from ZAP-70(+)/CD38(+) patients exhibited significantly shorter average telomere lengths than ZAP-70(-)/CD38(-) patients. Compared to the age-related percentiles of telomere length values from healthy individuals practically all values of the naive and memory T-cells from the ZAP-70(+)/CD38(+) CLL patients fell below the 50th percentile. This indicated an extensive expansion and a role for T-cells in ZAP-70(+)/CD38(+) CLL patients.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
de Beer, Dirk, Baerlocher, Gabriela M. |
ISSN: |
0007-1048 |
ISBN: |
18759763 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1111/j.1365-2141.2008.07363.x |
PubMed ID: |
18759763 |
Web of Science ID: |
000260117300010 |
URI: |
https://boris.unibe.ch/id/eprint/26913 (FactScience: 97207) |
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