Bieri, Michael; Oroszlan, Melinda; Zuppinger, Christian; Mohacsi, Paul J (2009). Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway. Molecular immunology, 46(5), pp. 866-72. Amsterdam: Elsevier 10.1016/j.molimm.2008.09.011
Full text not available from this repository. (Request a copy)Vascular endothelial (VE)-cadherin is an essential protein of adherens junctions of endothelial cells and plays a pivotal role in vascular homeostasis. Mammalian target of rapamycin complex 2 (mTORC2) deficient mice display defects in fetal vascular development. Blocking mTOR or the upstream kinase phosphoinositide 3-kinase (PI3K) led to a dose-dependently decrease of the VE-cadherin mRNA and protein expression. Immunofluorescent staining showed a strongly decreased expression of VE-cadherin at the interface of human umbilical endothelial cells (HUVECs) followed by intercellular gap formation. Herewith, we demonstrated that the expression of VE-cadherin is dependent on mTOR and PI3K signaling.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Oroszlan, Melinda, Zuppinger, Christian, Mohacsi, Paul |
ISSN: |
0161-5890 |
ISBN: |
18990449 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1016/j.molimm.2008.09.011 |
PubMed ID: |
18990449 |
Web of Science ID: |
000263942200013 |
URI: |
https://boris.unibe.ch/id/eprint/26990 (FactScience: 99381) |
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