Niggli, Verena; Sigel, Erwin (2008). Anticipating antiport in P-type ATPases. Trends in biochemical sciences, 33(4), pp. 156-60. Cambridge: Elsevier Current Trends 10.1016/j.tibs.2007.12.005
Full text not available from this repository. (Request a copy)Cation-transporting P-type ATPases show a high degree of structural and functional homology. Nevertheless, for many members of this large family, the molecular mechanism of transport is unclear; namely, whether transport is electrogenic or not and if countertransport is involved remains to be established. In a few well-studied cases such as the Na(+)-K(+)-ATPase, plasma membrane Ca(2+) ATPase (PMCA) and sarcoplasmic reticulum Ca(2+) ATPase (SERCA) countertransport has been clearly demonstrated. New data based on the crystal structure of SERCA now strongly indicate that countertransport could be mandatory for all P-type ATPases. This concept should be verified for other known and for all newly characterized P-type ATPases.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Niggli, Verena, Sigel, Erwin |
ISSN: |
0968-0004 |
ISBN: |
18343670 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1016/j.tibs.2007.12.005 |
PubMed ID: |
18343670 |
Web of Science ID: |
000255447900002 |
URI: |
https://boris.unibe.ch/id/eprint/27139 (FactScience: 104443) |
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