Ambulatory arterial stiffness index is increased in hypertensive childhood disease

Simonetti, Giacomo D; VON Vigier, Rodo O; Wühl, Elke; Mohaupt, Markus G (2008). Ambulatory arterial stiffness index is increased in hypertensive childhood disease. Pediatric research, 64(3), pp. 303-7. New York, N.Y.: Nature Publishing Group 10.1203/PDR.0b013e31817d9bc5

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Arterial hypertension in adults is often associated with an increased arterial stiffness, which correlates with the ambulatory arterial stiffness index (AASI) as derived from ambulatory blood pressure (BP) measurements. The purpose of this study was to demonstrate whether children with diagnosed hypertension have an increased AASI as in hypertensive adults. AASI was calculated from 185 ambulatory BP measurements of 114 hypertensive and 71 normotensive, healthy children. Hypertensive children had higher AASI values compared with their normotensive healthy counterparts (0.370 +/- 0.120 versus 0.204 +/- 0.199, p < 0.0001). Children with longer duration of hypertension or a history of primary or secondary aortic coarctation displayed even more elevated AASI values. A receiver operator curve derived cut-off of AASI set at 0.301 distinguished (p < 0.0001) hypertensive from normotensive children with an odds ratio of 8.2, a sensitivity of 81%, and a specificity of 65%. Moreover, AASI correlated with pulse and systolic BP. In conclusion, AASI is elevated in hypertensive children and correlates with the duration and the origin of hypertension in childhood.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Simonetti, Giacomo, von Vigier, Rodo, Mohaupt, Markus
ISSN:	0031-3998
ISBN:	18458657
Publisher:	Nature Publishing Group
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 15:03
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1203/PDR.0b013e31817d9bc5
PubMed ID:	18458657
Web of Science ID:	000258906700017
URI:	https://boris.unibe.ch/id/eprint/27242 (FactScience: 105137)