Simonetti, Giacomo D; Eisenberger, Ute; Bergmann, Ivo P; Frey, Felix J; Mohaupt, Markus G (2008). Pulse contour analysis: a valid assessment of central arterial stiffness in children? Pediatric nephrology, 23(3), pp. 439-44. Berlin: Springer-Verlag 10.1007/s00467-007-0693-x
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In adults the contour analysis of peripheral pressure waves in the upper limb reflects central aortic stiffness. Here, we wanted to demonstrate the appropriateness of pulse contour analysis to assess large artery stiffness in children. Digital volume pulse analysis, with the computation of the stiffness index and pulse wave velocity between carotid and femoral artery, were simultaneously determined in 79 healthy children between 8 years and 15 years (mean age 11.4 years, 32 girls). The stiffness index of 42 healthy adults (mean age 45.6 years, 26 women) served as control. Pulse wave velocity between carotid and femoral artery was directly correlated with systolic pressure and mean blood pressure, as well as with pulse pressure. The results from the stiffness index of children revealed the expected values extrapolated from the linear regression of adulthood stiffness index vs. age. Childhood stiffness index positively correlated with pulse wave velocity (r(2) = 0.07, P = 0.02) but not with blood pressure parameters. The exclusion of individuals with an increased vascular tone, as indicated by a reflexion index > 90%, improved the correlation between stiffness index and pulse wave velocity (r(2) = 0.13, P = 0.001). Our data indicate that digital volume pulse-based analysis has limitations if compared with pulse wave velocity to measure arterial stiffness, mostly in patients with a high vascular tone.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Simonetti, Giacomo, Eisenberger, Ute, Bergmann, Ivo Peter, Frey, Felix (B), Mohaupt, Markus |
ISSN: |
0931-041X |
ISBN: |
18097689 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:03 |
Last Modified: |
29 Mar 2023 23:33 |
Publisher DOI: |
10.1007/s00467-007-0693-x |
PubMed ID: |
18097689 |
Web of Science ID: |
000252694200014 |
BORIS DOI: |
10.7892/boris.27243 |
URI: |
https://boris.unibe.ch/id/eprint/27243 (FactScience: 105139) |
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