Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI

Welsch, GH; Trattnig, S; Scheffler, K; Szomonanyi, P; Quirbach, S; Marlovits, S; Domayer, S; Bieri, O; Mamisch, TC (2008). Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI. Journal of magnetic resonance imaging, 28(4), pp. 979-86. Hoboken, N.J.: Wiley Interscience 10.1002/jmri.21516

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PURPOSE: To use magnetization transfer (MT) imaging in the visualization of healthy articular cartilage and cartilage repair tissue after different cartilage repair procedures, and to assess global as well as zonal values and compare the results to T2-relaxation. MATERIALS AND METHODS: Thirty-four patients (17 after microfracture [MFX] and 17 after matrix-associated autologous cartilage transplantation [MACT]) were examined with 3T MRI. The MT ratio (MTR) was calculated from measurements with and without MT contrast. T2-values were evaluated using a multiecho, spin-echo approach. Global (full thickness of cartilage) and zonal (deep and superficial aspect) region-of-interest assessment of cartilage repair tissue and normal-appearing cartilage was performed. RESULTS: In patients after MFX and MACT, the global MTR of cartilage repair tissue was significantly lower compared to healthy cartilage. In contrast, using T2, cartilage repair tissue showed significantly lower T2 values only after MFX, whereas after MACT, global T2 values were comparable to healthy cartilage. For zonal evaluation, MTR and T2 showed a significant stratification within healthy cartilage, and T2 additionally within cartilage repair tissue after MACT. CONCLUSION: MT imaging is capable and sensitive in the detection of differences between healthy cartilage and areas of cartilage repair and might be an additional tool in biochemical cartilage imaging. For both MTR and T2 mapping, zonal assessment is desirable.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery
UniBE Contributor:	Mamisch, Tallal Charles
ISSN:	1053-1807
ISBN:	18821633
Publisher:	Wiley Interscience
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:03
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1002/jmri.21516
PubMed ID:	18821633
Web of Science ID:	000259791300020
URI:	https://boris.unibe.ch/id/eprint/27467 (FactScience: 107817)