[Safety of treatment with tacrolimus ointment for anterior segment inflammatory diseases]

Wyrsch, S; Thiel, M A; Becht, C N (2009). [Safety of treatment with tacrolimus ointment for anterior segment inflammatory diseases]. Klinische Monatsblätter für Augenheilkunde, 226(4), pp. 234-6. Stuttgart: Ferdinand Enke Verlag 10.1055/s-0028-1109328

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BACKGROUND: The off-label use of topical tacrolimus (Protopic) for inflammatory external eye diseases is gaining popularity. However, there are no reports on the safety profile of this new treatment option. PATIENTS AND METHODS: We treated six patients with different inflammatory eye diseases with topical tacrolimus (Protopic 0.03 %) as off-label use in addition to the conventional anti-inflammatory treatment. Patients were interviewed for side effects and serum drug concentrations were measured under steady state conditions one hour after topical application of tacrolimus ointment. RESULTS: Two patients reported a slight burning sensation immediately after application, in one patient we found a slight worsening of the dry eye problems. No patient abandoned the treatment due to side effects. Serum drug concentrations remained below the analytical threshold in all cases (< 1.5 ng/ml). CONCLUSIONS: Tacrolimus for the topical treatment of anterior segment inflammatory eye diseases is well tolerated without detectable systemic drug resorption.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Wyrsch, Stefan

ISSN:

0023-2165

ISBN:

19384773

Publisher:

Ferdinand Enke Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

05 Dec 2022 14:20

Publisher DOI:

10.1055/s-0028-1109328

PubMed ID:

19384773

Web of Science ID:

000265747900006

URI:

https://boris.unibe.ch/id/eprint/28270 (FactScience: 119069)

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