Casu, Laura; Bonsignore, Leonardo; Pinna, Manuela; Casu, Mariano; Floris, Costantino; Gertsch, Jürg; Cottiglia, Filippo (2006). Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus. Journal of natural products, 69(2), pp. 295-8. Washington, D.C.: American Chemical Society 10.1021/np0504513
Full text not available from this repository. (Request a copy)Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC(50) values ranging from 4 to 6 microM.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Gertsch, Jürg |
ISSN: |
0163-3864 |
ISBN: |
16499337 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:05 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1021/np0504513 |
PubMed ID: |
16499337 |
Web of Science ID: |
000235943400026 |
URI: |
https://boris.unibe.ch/id/eprint/28329 (FactScience: 120063) |
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