Rösler, Kai M; Roth, Denise M; Magistris, Michel R (2008). Trial-to-trial size variability of motor-evoked potentials. A study using the triple stimulation technique. Experimental brain research, 187(1), pp. 51-9. Berlin: Springer-Verlag 10.1007/s00221-008-1278-z
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Motor-evoked potentials (MEPs) vary in size from one stimulus to the next. The objective of this study was to determine the cause and source of trial-to-trial MEP size variability. In two experiments involving 10 and 14 subjects, the variability of MEPs to cortical stimulation (cortical-MEPs) in abductor digiti minimi (ADM) and abductor hallucis (AH) was compared to those responses obtained using the triple stimulation technique (cortical-TST). The TST eliminates the effects of motor neuron (MN) response desynchronization and of repetitive MN discharges. Submaximal stimuli were used in both techniques. In six subjects, cortical-MEP variability was compared to that of brainstem-MEP and brainstem-TST. Variability was greater for MEPs than that for TST responses, by approximately one-third. The variability was the same for cortical- and brainstem-MEPs and was similar in ADM and AH. Variability concerned at least 10-15% of the MN pool innervating the target muscle. With the stimulation parameters used, repetitive MN discharges did not influence variability. For submaximal stimuli, approximately two-third of the observed MEP size variability is caused by the variable number of recruited alpha-MNs and approximately one-third by changing synchronization of MN discharges. The source of variability is most likely localized at the spinal segmental level.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Rösler, Kai Michael, Roth, Denise Margrit |
ISSN: |
0014-4819 |
ISBN: |
18231784 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:05 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1007/s00221-008-1278-z |
PubMed ID: |
18231784 |
Web of Science ID: |
000255058400006 |
BORIS DOI: |
10.7892/boris.28486 |
URI: |
https://boris.unibe.ch/id/eprint/28486 (FactScience: 120970) |
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