Rothschild, Sacha; Ciernik, I Frank; Hartmann, Matthias; Schuknecht, Bernhard; Lütolf, Urs M; Huber, Alexander M (2009). Cholesteatoma triggering squamous cell carcinoma: case report and literature review of a rare tumor. American journal of otolaryngology, 30(4), pp. 256-60. Philadelphia, Pa.: Elsevier 10.1016/j.amjoto.2008.06.011
Full text not available from this repository. (Request a copy)BACKGROUND: The aim of this study was to report a case of squamous cell carcinoma of the petrous part of the temporal bone associated with a long history of secondary acquired cholesteatoma in a 71-year-old man. PATIENTS AND METHODS: We present the case of a 71-year-old man diagnosed with secondary acquired cholesteatoma in 1950. Treatments consisted of repetitive surgery owing to several relapses. In 2004, he presented with progressive fetid otorrhea. Clinical and computed tomography findings were indicative for relapsing cholesteatoma and a subtotal petrosectomy was performed. RESULTS: Histologic work-up demonstrated a moderately differentiated squamous cell carcinoma. The staging revealed stadium pT3 cN0 cM0. Postoperative treatment consisted of local radiation therapy with intensity-modulated beam geometry with a total of 64.2 Gy in 30 fractions using a simultaneous integrated boost. CONCLUSION: Middle ear carcinoma can arise from acquired cholesteatoma. The pathogenesis of squamous cell carcinoma associated with cholesteatoma has not been elucidated satisfactorily. Due to the complex anatomic features, intensity-modulated radiation therapy is the technique of choice for postoperative radiotherapy.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Rothschild, Sacha |
ISSN: |
0196-0709 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:11 |
Last Modified: |
05 Dec 2022 14:21 |
Publisher DOI: |
10.1016/j.amjoto.2008.06.011 |
PubMed ID: |
19563937 |
Web of Science ID: |
000267921100008 |
URI: |
https://boris.unibe.ch/id/eprint/31389 (FactScience: 195887) |
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