Schmid, L; Müller, M; Treumann, T; Arnold, W; Möller, B; Aeberli, D; Villiger, P M (2009). Induction of complete and sustained remission of rheumatoid pachymeningitis by rituximab. Arthritis & rheumatism, 60(6), pp. 1632-4. Hoboken, N.J.: Wiley-Blackwell 10.1002/art.24577
Full text not available from this repository. (Request a copy)Aseptic pachymeningitis is a rare and serious complication of rheumatoid arthritis (RA). Herein, we describe a patient with rheumatoid factor-positive and anti-cyclic citrullinated peptide-positive RA who experienced a focal seizure, with aphasia and convulsions of the right side of the body. The findings of magnetic resonance imaging and histologic analysis led to a diagnosis of rheumatoid pachymeningitis. Because the patient had a large number of CD20-expressing B lymphocytes, therapy with rituximab was started and has resulted in complete and sustained remission of both the pachymeningitis and the RA for >2 years. Despite a decrease in immunoglobulins, the patient has remained free of infections, which illustrates the favorable outcome that can result from therapeutic B cell depletion in this potentially lethal manifestation of RA.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology |
UniBE Contributor: |
Möller, Burkhard, Villiger, Peter Matthias |
ISSN: |
0004-3591 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:11 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.1002/art.24577 |
PubMed ID: |
19479865 |
Web of Science ID: |
000267116800011 |
URI: |
https://boris.unibe.ch/id/eprint/31407 (FactScience: 195914) |
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