Combination of gonadotropin-releasing hormone (GnRH) agonists with GnRH antagonists before chemotherapy reduce but does not completely prevent a follicle-stimulating hormone flare-up

von Wolff, Michael; Kämmerer, Ulrike; Kollmann, Zahraa; Santi, Alessandro; Dietl, Johannes; Frambach, Torsten (2011). Combination of gonadotropin-releasing hormone (GnRH) agonists with GnRH antagonists before chemotherapy reduce but does not completely prevent a follicle-stimulating hormone flare-up. Fertility and sterility, 95(1), pp. 452-4. New York, N.Y.: Elsevier 10.1016/j.fertnstert.2010.08.053

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Increasing evidence supports GnRH agonists to be an effective treatment to preserve ovarian function during chemotherapy, but the initial flare-up of FSH during the first week after GnRH agonist application still limits its use. The combination of GnRH agonists with GnRH antagonists might solve this problem to some extent as the addition of GnRH antagonists at least significantly reduces the FSH flare-up.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

von Wolff, Michael, Santi, Alessandro

ISSN:

0015-0282

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:14

Last Modified:

05 Dec 2022 14:02

Publisher DOI:

10.1016/j.fertnstert.2010.08.053

PubMed ID:

20869706

Web of Science ID:

000285411600120

URI:

https://boris.unibe.ch/id/eprint/3274 (FactScience: 206913)

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