Hackl, Hubert; Rommer, Anna; Konrad, Torsten A; Nassimbeni, Christine; Wieser, Rotraud (2010). Tetracycline regulator expression alters the transcriptional program of mammalian cells. PLoS ONE, 5(9), e13013. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0013013
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Tetracycline regulated ectopic gene expression is a widely used tool to study gene function. However, the tetracycline regulator (tetR) itself has been reported to cause certain phenotypic changes in mammalian cells. We, therefore, asked whether human myeloid U937 cells expressing the tetR in an autoregulated manner would exhibit alterations in gene expression upon removal of tetracycline.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Konrad, Torsten |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:14 |
Last Modified: |
05 Dec 2022 14:02 |
Publisher DOI: |
10.1371/journal.pone.0013013 |
PubMed ID: |
20886048 |
Web of Science ID: |
000282122600025 |
BORIS DOI: |
10.7892/boris.3368 |
URI: |
https://boris.unibe.ch/id/eprint/3368 (FactScience: 207038) |
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