Andersen, T V; Schmidt, L S; Poulsen, A H; Feychting, M; Röösli, M; Tynes, T; Aydin, D; Prochazka, M; Lannering, B; Klæboe, L; Eggen, T; Kuehni, C E; Schmiegelow, K; Schüz, J (2013). Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO). British journal of cancer, 108(11), pp. 2346-2353. Nature Publishing Group 10.1038/bjc.2013.201
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BACKGROUND
Infectious diseases and social contacts in early life have been proposed to modulate brain tumour risk during late childhood and adolescence.
METHODS
CEFALO is an interview-based case-control study in Denmark, Norway, Sweden and Switzerland, including children and adolescents aged 7-19 years with primary intracranial brain tumours diagnosed between 2004 and 2008 and matched population controls.
RESULTS
The study included 352 cases (participation rate: 83%) and 646 controls (71%). There was no association with various measures of social contacts: daycare attendance, number of childhours at daycare, attending baby groups, birth order or living with other children. Cases of glioma and embryonal tumours had more frequent sick days with infections in the first 6 years of life compared with controls. In 7-19 year olds with 4+ monthly sick day, the respective odds ratios were 2.93 (95% confidence interval: 1.57-5.50) and 4.21 (95% confidence interval: 1.24-14.30).
INTERPRETATION
There was little support for the hypothesis that social contacts influence childhood and adolescent brain tumour risk. The association between reported sick days due to infections and risk of glioma and embryonal tumour may reflect involvement of immune functions, recall bias or inverse causality and deserve further attention.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Kühni, Claudia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0007-0920 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Beatrice Minder Wyssmann |
Date Deposited: |
19 Feb 2014 14:41 |
Last Modified: |
05 Dec 2022 14:27 |
Publisher DOI: |
10.1038/bjc.2013.201 |
PubMed ID: |
23652309 |
BORIS DOI: |
10.7892/boris.40776 |
URI: |
https://boris.unibe.ch/id/eprint/40776 |
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