Cochet, Hubert; Komatsu, Yuki; Sacher, Frederic; Jadidi, Amir Sherwan; Scherr, Daniel; Riffaud, Matthieu; Derval, Nicolas; Shah, Ashok; Roten, Laurent; Pascale, Patrizio; Relan, Jatin; Sermesant, Maxime; Ayache, Nicholas; Montaudon, Michel; Laurent, François; Hocini, Mélèze; Haïssaguerre, Michel; Jaïs, Pierre (2013). Integration of merged delayed-enhanced magnetic resonance imaging and multidetector computed tomography for the guidance of ventricular tachycardia ablation: a pilot study. Journal of cardiovascular electrophysiology, 24(4), pp. 419-26. Wiley-Blackwell 10.1111/jce.12052
Full text not available from this repository. (Request a copy)BACKGROUND
Delayed enhancement (DE) MRI can assess the fibrotic substrate of scar-related VT. MDCT has the advantage of inframillimetric spatial resolution and better 3D reconstructions. We sought to evaluate the feasibility and usefulness of integrating merged MDCT/MRI data in 3D-mapping systems for structure-function assessment and multimodal guidance of VT mapping and ablation.
METHODS
Nine patients, including 3 ischemic cardiomyopathy (ICM), 3 nonischemic cardiomyopathy (NICM), 2 myocarditis, and 1 redo procedure for idiopathic VT, underwent MRI and MDCT before VT ablation. Merged MRI/MDCT data were integrated in 3D-mapping systems and registered to high-density endocardial and epicardial maps. Low-voltage areas (<1.5 mV) and local abnormal ventricular activities (LAVA) during sinus rhythm were correlated to DE at MRI, and wall-thinning (WT) at MDCT.
RESULTS
Endocardium and epicardium were mapped with 391 ± 388 and 1098 ± 734 points per map, respectively. Registration of MDCT allowed visualization of coronary arteries during epicardial mapping/ablation. In the idiopathic patient, integration of MRI data identified previously ablated regions. In ICM patients, both DE at MRI and WT at MDCT matched areas of low voltage (overlap 94 ± 6% and 79 ± 5%, respectively). In NICM patients, wall-thinning areas matched areas of low voltage (overlap 63 ± 21%). In patients with myocarditis, subepicardial DE matched areas of epicardial low voltage (overlap 92 ± 12%). A total number of 266 LAVA sites were found in 7/9 patients. All LAVA sites were associated to structural substrate at imaging (90% inside, 100% within 18 mm).
CONCLUSION
The integration of merged MDCT and DEMRI data is feasible and allows combining substrate assessment with high-spatial resolution to better define structure-function relationship in scar-related VT.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Roten, Laurent |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1045-3873 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Laurent Roten |
Date Deposited: |
25 Feb 2014 11:50 |
Last Modified: |
05 Dec 2022 14:28 |
Publisher DOI: |
10.1111/jce.12052 |
PubMed ID: |
23252727 |
URI: |
https://boris.unibe.ch/id/eprint/42253 |
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