Medeiros Domingo, Argelia; Iturralde-Torres, Pedro; Canizales-Quinteros, Samuel; Hernández-Cruz, Arturo; Tusié-Luna, M. Teresa (2007). New perspectives in long QT syndrome. Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición, 59(1), pp. 57-72. Instituto Nacional de la Nutricion "Salvador Zubiran"
Full text not available from this repository. (Request a copy)Long QT Syndrome (LQTS) is a cardiac channelopathy characterized by prolonged ventricular repolarization and increased risk to sudden death secondary to ventricular dysrrhythmias. Was the first cardiac channelopathy described and is probably the best understood. After a decade of the sentinel identification of ion channel mutation in LQTS, genotype-phenotype correlations have been developed along with important improvement in risk stratification and genetic guided-treatment. Genetic screening has shown that LQTS is more frequent than expected and interestingly, ethnic specific polymorphism conferring increased susceptibility to drug induced QT prolongation and torsades de pointes have been identified. A better understanding of ventricular arrhythmias as an adverse effect of ion channel binding drugs, allow the development of more safety formulas and better control of this public health problem. Progress in understanding the molecular basis of LQTS has been remarkable; eight different genes have been identified, however still 25% of patients remain genotype-negative. This article is an overview of the main LQTS knowledge developed during the last years.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Medeiros Domingo, Argelia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0034-8376 |
Publisher: |
Instituto Nacional de la Nutricion "Salvador Zubiran" |
Language: |
Español |
Submitter: |
Argelia Medeiros Domingo |
Date Deposited: |
13 Jun 2014 16:46 |
Last Modified: |
05 Dec 2022 14:28 |
PubMed ID: |
17569301 |
URI: |
https://boris.unibe.ch/id/eprint/42289 |
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