Kronenberg, Andreas; Hilty, M.; Endimiani, A.; Mühlemann, Kathrin (2013). Temporal trends of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in in- and outpatients in Switzerland, 2004 to 2011. Euro surveillance, 18(21), p. 20484. Institut de Veille Sanitaire
|
Text
art20484.pdf - Published Version Available under License Publisher holds Copyright. Download (377kB) | Preview |
Increasing trends for invasive infections with extended-spectrum cephalosporin-resistant (ESC-R) Enterobacteriaceae have been described in many countries worldwide. However, data on the rates of ESC-R isolates in non-invasive infections and in the outpatient setting are scarce. We used a laboratory-based nationwide surveillance system to compare temporal trends of ESC-R rates in Escherichia coli and Klebsiella pneumoniae for in- and outpatients in Switzerland. Our data showed a significant increase in ESC-R rates from 1% to 5.8% in E. coli (p<0.001) and from 1.1% to 4.4% in K. pneumoniae (p=0.002) during an eight-year period (2004–2011). For E. coli, the increase was significantly higher in inpatients (from 1.2% to 6.6%), in patients residing in eastern Switzerland (from 1.0% to 6.2%), in patients older than 45 years (from 1.2% to 6.7%), and in male patients (from 1.2% to 8.1%). While the increase in inpatients was linear (p<0.001) for E. coli, the increase of ESC R K. pneumoniae isolates was the result of multiple outbreaks in several institutions. Notably, an increasing proportion of ESC-R E. coli was co-resistant to both trimethoprim-sulfamethoxazole and quinolones (42% in 2004 to 49.1% in 2011, p=0.009), further limiting the available oral therapeutic options.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Kronenberg, Andreas Oskar, Hilty, Markus, Endimiani, Andrea, Mühlemann, Kathrin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1025-496X |
Publisher: |
Institut de Veille Sanitaire |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
21 Mar 2014 11:02 |
Last Modified: |
05 Dec 2022 14:29 |
PubMed ID: |
23725981 |
BORIS DOI: |
10.7892/boris.44300 |
URI: |
https://boris.unibe.ch/id/eprint/44300 |
Actions (login required)
 |
Edit item |