Graus-Porta, Diana; Blaess, Sandra; Senften, Mathias; Littlewood-Evans, Amanda; Damsky, Caroline; Huang, Zhen; Orban, Paul; Klein, Rüdiger; Schittny, Johannes C.; Müller, Ulrich (2001). β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex. Neuron, 31(3), pp. 367-379. Cell Press 10.1016/S0896-6273(01)00374-9
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Mice that lack all beta1-class integrins in neurons and glia die prematurely after birth with severe brain malformations. Cortical hemispheres and cerebellar folia fuse, and cortical laminae are perturbed. These defects result from disorganization of the cortical marginal zone, where beta1-class integrins regulate glial endfeet anchorage, meningeal basement membrane remodeling, and formation of the Cajal-Retzius cell layer. Surprisingly, beta1-class integrins are not essential for neuron-glia interactions and neuronal migration during corticogenesis. The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy |
UniBE Contributor: |
Schittny, Johannes |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0896-6273 |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Johannes Schittny |
Date Deposited: |
25 Aug 2014 15:01 |
Last Modified: |
05 Dec 2022 14:33 |
Publisher DOI: |
10.1016/S0896-6273(01)00374-9 |
PubMed ID: |
11516395 |
BORIS DOI: |
10.7892/boris.50156 |
URI: |
https://boris.unibe.ch/id/eprint/50156 |
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