Impairments in an early stage of the decision-making process in patients with ventromedial prefrontal damage: preliminary results

Eggen, Céline; Huber, Oswald; Bär, Arlette; Huber, Odilo W.; Perrig, Walter J.; Müri, René Martin; Gutbrod, Klemens (2014). Impairments in an early stage of the decision-making process in patients with ventromedial prefrontal damage: preliminary results. Neurocase, 21(4), pp. 509-519. Oxford University Press 10.1080/13554794.2014.944545

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Lesions of the ventromedial prefrontal cortex can result in a deficient decision-making behavior. So far, most experimental results in the neuropsychological decision-making research have been obtained with gambling tasks. Due to their high complexity, it is difficult to evaluate the underlying processes of the decision-making deficits. The aim of this study was to assess if patients with ventromedial prefrontal damage compared to patients with dorsolateral prefrontal damage and controls show a deficit in an early stage of the decision-making process. Nine patients with ventromedial prefrontal damage, three with dorsolateral prefrontal damage, and eleven healthy controls were tested with a newly developed decision task in which they had to search actively for the information they needed for their decisions. Our results show that patients with ventromedial prefrontal damage compared to the brain-lesioned dorsolateral prefrontal control group and healthy controls searched less for information with regard to risk defusing operators or consequences of their decisions indicating impairment already in the early stage of the decision-making process.

Item Type: Journal Article (Original Article)
Division/Institute: 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology > Experimental Psychology and Neuropsychology
10 Strategic Research Centers > Center for Cognition, Learning and Memory (CCLM)
UniBE Contributor: Perrig, Walter; Müri, René Martin and Gutbrod, Klemens
Subjects: 600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology
ISSN: 1355-4794
Publisher: Oxford University Press
Language: English
Submitter: Anna Maria Ruprecht
Date Deposited: 12 Sep 2014 14:32
Last Modified: 26 Jun 2016 01:53
Publisher DOI: 10.1080/13554794.2014.944545
PubMed ID: 25080839
Uncontrolled Keywords: decision-making, ventromedial prefrontal cortex
BORIS DOI: 10.7892/boris.58206
URI: http://boris.unibe.ch/id/eprint/58206

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