Therrien, Bruno; Furrer, Julien (2014). The Biological Side of Water-Soluble Arene Ruthenium Assemblies. Advances in chemistry, 2014, pp. 1-20. Hindawi 10.1155/2014/589686
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This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors. The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers. On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors. The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release. The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins. These metalla-assemblies demonstrate great prospective in photodynamic therapy.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Furrer, Julien |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
2356-6612 |
Publisher: |
Hindawi |
Language: |
English |
Submitter: |
Julien Henri Lucien Furrer |
Date Deposited: |
03 Oct 2014 14:42 |
Last Modified: |
05 Dec 2022 14:37 |
Publisher DOI: |
10.1155/2014/589686 |
BORIS DOI: |
10.7892/boris.58844 |
URI: |
https://boris.unibe.ch/id/eprint/58844 |
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