Eggimann, Gabriela A.; Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Kammer, Stephan M.; Darbre, Tamis; Reymond, Jean-Louis (2014). Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chemical communications, 50(55), pp. 7254-7257. Royal Society of Chemistry 10.1039/C4CC02780A
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Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Blattes, Emilyne, Buschor, Stefanie, Biswas, Rasomoy, Darbre, Tamis, Reymond, Jean-Louis |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 600 Technology > 610 Medicine & health |
ISSN: |
1359-7345 |
Publisher: |
Royal Society of Chemistry |
Language: |
English |
Submitter: |
Xian Jin |
Date Deposited: |
10 Nov 2014 09:40 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1039/C4CC02780A |
BORIS DOI: |
10.7892/boris.60006 |
URI: |
https://boris.unibe.ch/id/eprint/60006 |
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